ceesdekker.net - An Overview
ceesdekker.net - An Overview
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Spatial framework facilitates cooperation in the social Predicament: empirical proof from a bacterial Local community
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Nanofabrication of electrodes with sub-5 nm spacing for transportation experiments on one molecules and metal clusters
Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond clever structure in 2005. (nl)
SMC complexes can pass physical roadblocks larger than their ring dimensions, indicating a nontopological system for DNA loop extrusion
We use nanofabricated microfluidic buildings to sample spatial boundaries for micro organism and biomimetic vesicles with reconstituted protein networks which assess the basic part of spatial confinement on the molecular and cellular level. Our projects include the subsequent:
Nanopores symbolize a chic and adaptable Device to measure solitary molecules. We analysis novel detection modes with sound-condition nanopores along with different strategies to measure proteins with nanopores. Assignments encompass the next:
2003, shown the 1st biosensors designed away from a carbon nanotube; settled the structure and system of DNA maintenance proteins; and discovery of a different strategy for fabricating sound-state nanopores for DNA translocation
Dekker begun his analysis on single carbon nanotubes in 1993 when he create a different line of investigate to study electrical transport by way of one natural molecules concerning nanoelectrodes. In 1996 a breakthrough was understood with carbon nanotubes. This was accomplished inside a collaboration with the team of Nobel laureate Richard Smalley. STM and nanolithography techniques ended up used to reveal that these nanotubes are quantum wires at The only-molecule amount, with exceptional Actual physical Attributes.
Given that 2000 he moved to one-molecule biophysics and nanobiology, with investigation from research of DNA loop extrusion and supercoiling to DNA translocation as a result of nanopores. Far more lately his investigate has focused on researching chromatin construction and mobile division with microorganisms on chip, while he can be attempting to in the long run Develop artificial cells from the bottom up.
Character Physics thanks the nameless reviewers for their contribution into the peer overview of this do the job.
One example is, we consider the nucleopore complicated, a gateway between the mobile nucleus along with the cytoplasm. This is an extremely difficult method and therefore tricky to examine inside a mobile, so we use biomimetics. We reconstruct holes then insert personal elements of your nucleopore intricate https://www.ceesdekker.net to study transportation by means of it at The one-molecule degree.’
It had been an exceptionally fascinating time, for the duration of which I been given plenty of guidance from Delft College of Engineering, wherever I had been a professor at the time, and I commenced quite a few collaborations with molecular biologists. That helped me find out quite a bit.’